definitely keep the same back 3.
I'd also stick with the midfield 2, and give Downes more time to heal, while we player a lesser opposition.
I'd look to rotate further up the pitch. Bring Manning in at left wingback, and push Hannes further forward, resting Patterson.
Piroe and Obafemi seem to be buzzing. So start them, but if we are comfortably ahead, take them off, and put Joseph up top, and use either Pato or Ntcham on for Piroe.